Antıfungal Actıvıty And Cytotoxıcıty Of Schıff Base Compounds And Theır Cu(Iı)/Zn(Iı) Complexes Agaınst Candıda Specıes.
5th INTERNATIONAL PARIS CONGRESS ON MEDICAL & HEALTH SCIENCES , 19 - 21 Temmuz 2026, ss.197-198, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Sayfa Sayıları: ss.197-198
- İstanbul Üniversitesi Adresli: Evet
Özet
Background: Candida species are among the most clinically significant fungal pathogens, and the steady rise in antifungal resistance has intensified the search for new antimicrobial scaffolds. Schiff bases (imine compounds) and their metal complexes are of particular interest owing to their chelating capacity and broad spectrum of reported biological activities. In this study, the antifungal activity and cytotoxicity of two salicylaldehydederived Schiff bases and their Cu(II) and Zn(II) complexes were investigated. Methods: Two Schiff bases methylphenyl)imino]methyl}benzene-1,4-diol, — and H3L1, H3L2, 2-{[(2-hydroxy-5 4-{[(2-hydroxy-5methylphenyl)imino]methyl}benzene-1,2-diol — were synthesized by condensation and reacted with CuCl₂ and ZnCl₂ to yield the complexes A2 (H3L1–Cu) and A1 (H3L2–Zn). Minimum inhibitory concentrations (MIC) were determined against standard bacterial and Candida strains and against 18 clinical Candida isolates following CLSI criteria. Cytotoxicity was assessed by MTT assay on CCD-1072Sk fibroblasts (9.7–625 µg/mL; read at 570 nm) in triplicate. Results: The copper complex A2 showed the most promising antifungal profile, with MIC values of 39.06–625 µg/mL against all tested Candida species, including clinical isolates of C. albicans, C. glabrata, C. guilliermondii, C. parapsilosis, and C. tropicalis. The zinc complex A1 displayed only limited activity against a few isolates. Both compounds were non-cytotoxic at their effective concentrations. Conclusion: Copper-coordinated Schiff base complexes appear to be a promising scaffold for novel antifungal agents amid rising resistance. Further mechanistic and in vivo studies are warranted