DIFFERENT EFFECTS OF CAV1 rs3807990 VARIATION ON LIPID PROFILE IN PATIENTS WITH CORONARY HEART DISEASE BASED ON PRESENCE OF DIABETES


Kurnaz-Gomleksiz O., Ilikay S., Bugra Z. , Ozturk O. , Aydogan H. Y.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.83, ss.23-29, 2020 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 83 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.26650/iuitfd.2018.0023
  • Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Sayfa Sayıları: ss.23-29

Özet

Objective: A decreased antiatherogenic function of endothelium causes endothelial dysfunction characterized by decreased nitric oxide (NO) levels. NO amounts can be regulated by the inhibition of eNOS enzyme activity via caveolin-1 (Cav-1). We aimed to determine the effect of CAV1 rs3807990 on metabolic and lipid biomarker levels in diabetic and non-diabetic coronary heart disease (CHD) and to determine the possible contribution to diabetic dyslipidemia.