Haemodiafiltration does not lower protein-bound uraemic toxin levels compared with haemodialysis in a paediatric population

Snauwaert, Evelien; Van Biesen, Wim; Raes, Ann; Glorieux, Griet; Vande Walle, Johan; Roels, Sanne; Vanholder, Raymond; Askiti, Varvara; Azukaitis, Karolis; KARABAY BAYAZIT, AYSUN; CANPOLAT, Nur; Fischbach, Michel; Saoussen, Krid; Litwin, Mieczyslaw; Obrycki, Lukasz; Paglialonga, Fabio; Ranchin, Bruno; Samaille, Charlotte; Schaefer, Franz; Schmitt, Claus; Spasojevic, Brankica; Stefanidis, Constantinos; Shroff, Rukshana; Eloot, Sunny

doi:10.1093/ndt/gfz132

Haemodiafiltration does not lower protein-bound uraemic toxin levels compared with haemodialysis in a paediatric population

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Snauwaert E., Van Biesen W., Raes A., Glorieux G., Vande Walle J., Roels S., ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.35, no.4, pp.648-656, 2020 (SCI-Expanded)

Publication Type: Article / Article
Volume: 35 Issue: 4
Publication Date: 2020
Doi Number: 10.1093/ndt/gfz132
Journal Name: NEPHROLOGY DIALYSIS TRANSPLANTATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Page Numbers: pp.648-656
Istanbul University Affiliated: No

Abstract

Background. Haemodiafiltration (HDF) is accepted to effectively lower plasma levels of middle molecules in the long term, while data are conflicting with respect to the additive effect of convection on lowering protein-bound uraemic toxins (PBUTs). Here we compared pre-dialysis beta 2-microglobulin (beta 2M) and PBUT levels and the percentage of protein binding (%PB) in children on post-dilution HDF versus conventional high- (hf) or low-flux (lf) haemodialysis (HD) over 12 months of treatment.