Serum neprilysin levels are elevated in preeclampsia


Tuten N., Malik E., Gok K., Hamzaoglu K., MAKUL M., ÖNER Y. Ö., ...More

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, vol.60, no.5, pp.869-873, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.1016/j.tjog.2021.07.015
  • Journal Name: TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.869-873
  • Keywords: Blood pressure, Enkephalinase, Endopeptidase, Natriuretic peptides, Neutral endopeptidase, HEART-FAILURE, NATRIURETIC PEPTIDES, NEUTRAL ENDOPEPTIDASE, SOLUBLE NEPRILYSIN, HUMAN PLACENTA, SYSTEM, INHIBITION, HYDROLYSIS, EXPRESSION, VILLI
  • Istanbul University Affiliated: No

Abstract

Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty -five consecutive women with mild preeclampsia and fifty -five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (+/- 1 week) women with an uncomplicated pregnancy. Results: Mean serum NEP was significantly higher in women with preeclampsia compared to that of the gestational age-matched-controls (231.62 +/- 65.30 pg/mL vs. 187.75 +/- 84.38 pg/mL, p < 0.001). Mean serum NEP was significantly higher in the mild preeclampsia group compared to its gestational age -matched control group (228.84 +/- 67.26 pg/mL vs. 186.14 +/- 85.09 pg/mL, p = 0.008); and in the severe preeclampsia group compared to its gestational age-matched control group (234.45 +/- 63.85 pg/mL vs. 189.29 +/- 84.59 pg/mL, p = 0.004). Serum NEP was positively correlated with systolic and diastolic blood pressure, BUN, uric acid, and creatinine. Conclusion: Mean serum NEP was significantly higher in women with preeclampsia than women with an uncomplicated pregnancy. Further studies are needed to elucidate the possible therapeutic role of NEP inhibitors to treat preeclampsia. (c) 2021 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).