Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women

Guclu-Geyik F., Erkan A. F., Ozuynuk A. S., Ekici B., Coban N.

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, vol.50, no.1, pp.34-46, 2022 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.5543/tkda.2022.21003
  • Journal Name: TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.34-46
  • Keywords: Intelectin-1, ITLN1 gene, coronary artery disease, Val109Asp, SERUM OMENTIN-1 LEVELS, ADIPOSE-TISSUE, RISK, ADIPOKINES, ATHEROSCLEROSIS, RECEPTOR, LIPIDS
  • Istanbul University Affiliated: Yes

Abstract

Objective: Intelectin-1 is an anti-inflammatory adipokine encoded by the Intelectin 1 (ITLN1) gene. Genetic variations in the ITLN1 gene affect the risk of coronary artery disease (CAD) and related CAD risk factors. In this study, we aimed to investigate whether the ITLN1 gene Val109Asp polymorphism has an effect on the severity of CAD and serum lipid levels in both men and women.