Tibolone and breast cancer


Erel C. T. , Senturk L. M. , Kaleli S.

POSTGRADUATE MEDICAL JOURNAL, cilt.82, ss.658-662, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 82 Konu: 972
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1136/pgmj.2005.037184
  • Dergi Adı: POSTGRADUATE MEDICAL JOURNAL
  • Sayfa Sayıları: ss.658-662

Özet

Tibolone is a relatively new drug for postmenopausal women, which is structurally related to 19-nortestosterone derivatives and exhibits weak oestrogenic, progestogenic and androgenic activities. The effect of tibolone on breast tissue is still obscure. In vitro studies have shown conflicting results regarding the effects of tibolone on breast cells. On the other hand, although epidemiological studies show an increase in the risk of breast cancer among women treated with tibolone, accumulation of data obtained from radiological studies presents promising results. However, the safety of tibolone with regard to breast tissue needs to be investigated further, especially through well- designed, large-scale, randomised-controlled trials.