Molecularly Imprinted Nanoparticle-Embedded Electrospun Mat as an Antibacterial Wound Dressing

Çerçi A., Akgün O., KARACA E., YÜCEL M., ARI F., Yiğit Çınar A., ...More

Polymers for Advanced Technologies, vol.36, no.2, 2025 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 2
  • Publication Date: 2025
  • Doi Number: 10.1002/pat.70100
  • Journal Name: Polymers for Advanced Technologies
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: amoxicillin, antibacterial wound dressing, drug release, electrospinning, molecular imprinting
  • Istanbul University Affiliated: Yes

Abstract

Molecularly imprinted polymer (MIP) nanoparticles offer a promising controlled drug delivery platform. In this study, amoxicillin (AMOX)-imprinted polymer nanoparticles (~60 nm) were synthesized via emulsion polymerization and incorporated into polyvinyl alcohol (PVA)/sodium alginate (SA) [PVS] electrospun nanofibers to develop a novel wound dressing. The nanoparticle-embedded PVS nanofibers (PVS-AMOX-MIP) demonstrated a sustained cumulative drug release of 43.6% over 2 days, governed by non-Fickian transport per the Korsmeyer–Peppas kinetic model. The nanofibers exhibited favorable physical properties, including a high specific surface area (39.66 m2/g), optimal porosity (78.8%), and a water vapor transmission rate (1053.4 ± 5.9 g/m2/day), ideal for wound healing. Antibacterial activity studies showed significant inhibition against Staphylococcus aureus and Escherichia coli, while biocompatibility assays confirmed the mat's noncytotoxic nature and ability to promote cell proliferation. Furthermore, angiogenesis studies revealed enhanced vascularization, which is critical for tissue regeneration. The developed strategy offers a unique approach for advanced wound care and controlled drug delivery applications by combining MIP nanoparticles' molecular recognition capability with the structural advantages of electrospun nanofibers.