Fragmentation Analysis of Plasma DNA Reveals Its Prognostic Value in Gastric Cancer

YÖRÜKER E. E., ÖZGÜR E., KESKİN M., ÖZGÜR İ., GEZER U.

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.32, sa.9, ss.720-726, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5152/tjg.2021.20832
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.720-726
  • Anahtar Kelimeler: Circulating nucleosome, DNA integrity, gastric cancer, plasma, CELL-FREE DNA, INTEGRITY, SERUM, NUCLEOSOMES, DIAGNOSIS, BENIGN, BLOOD, TOOL
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Gastric cancer (GC) is a common cause of cancer-related deaths. The poor clinical outcome in GC patients is partially associated with a lack of appropriate diagnostic and prognostic biomarkers. In the present study, we evaluated the diagnostic and prognostic values of cell-free DNA (cfDNA) integrity and the concentration of circulating nucleosomes (cNUCs).