Fragmentation Analysis of Plasma DNA Reveals Its Prognostic Value in Gastric Cancer

YÖRÜKER E. E., ÖZGÜR E., KESKİN M., ÖZGÜR İ., GEZER U.

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.32, no.9, pp.720-726, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.5152/tjg.2021.20832
  • Journal Name: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.720-726
  • Keywords: Circulating nucleosome, DNA integrity, gastric cancer, plasma, CELL-FREE DNA, INTEGRITY, SERUM, NUCLEOSOMES, DIAGNOSIS, BENIGN, BLOOD, TOOL
  • Istanbul University Affiliated: Yes

Abstract

Background: Gastric cancer (GC) is a common cause of cancer-related deaths. The poor clinical outcome in GC patients is partially associated with a lack of appropriate diagnostic and prognostic biomarkers. In the present study, we evaluated the diagnostic and prognostic values of cell-free DNA (cfDNA) integrity and the concentration of circulating nucleosomes (cNUCs).