Oncolytic adenoviral therapy in gallbladder carcinoma

Tekant Y. , Davydova J., Ramirez P., Curiel D., Vickers S., Yamamoto M.

SURGERY, cilt.137, ss.527-535, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 137 Konu: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.surg.2004.12.014
  • Dergi Adı: SURGERY
  • Sayfa Sayıları: ss.527-535


Background. Oncolytic adenoviral therapy is a promising new approach for cancer treatment. The aim of this study was to improve the conditionally replicative adenoviruses (CRAds) for gallbladder cancer therapy by modifying the fiber-knob region for infectivity enhancement and by incorporating tumor-specific promoters (TSPs) for enhanced specificity.