Oncolytic adenoviral therapy in gallbladder carcinoma

Tekant, YAMAN; Davydova, J; Ramirez, PJ; Curiel, DT; Vickers, SM; Yamamoto, M

doi:10.1016/j.surg.2004.12.014

Oncolytic adenoviral therapy in gallbladder carcinoma

Tekant Y., Davydova J., Ramirez P., Curiel D., Vickers S., Yamamoto M.

SURGERY, cilt.137, sa.5, ss.527-535, 2005 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 137 Sayı: 5
Basım Tarihi: 2005
Doi Numarası: 10.1016/j.surg.2004.12.014
Dergi Adı: SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.527-535
İstanbul Üniversitesi Adresli: Hayır

Özet

Background. Oncolytic adenoviral therapy is a promising new approach for cancer treatment. The aim of this study was to improve the conditionally replicative adenoviruses (CRAds) for gallbladder cancer therapy by modifying the fiber-knob region for infectivity enhancement and by incorporating tumor-specific promoters (TSPs) for enhanced specificity.