Oncolytic adenoviral therapy in gallbladder carcinoma

Tekant, YAMAN; Davydova, J; Ramirez, PJ; Curiel, DT; Vickers, SM; Yamamoto, M

doi:10.1016/j.surg.2004.12.014

Oncolytic adenoviral therapy in gallbladder carcinoma

Tekant Y., Davydova J., Ramirez P., Curiel D., Vickers S., Yamamoto M.

SURGERY, vol.137, no.5, pp.527-535, 2005 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 137 Issue: 5
Publication Date: 2005
Doi Number: 10.1016/j.surg.2004.12.014
Journal Name: SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.527-535
Istanbul University Affiliated: No

Abstract

Background. Oncolytic adenoviral therapy is a promising new approach for cancer treatment. The aim of this study was to improve the conditionally replicative adenoviruses (CRAds) for gallbladder cancer therapy by modifying the fiber-knob region for infectivity enhancement and by incorporating tumor-specific promoters (TSPs) for enhanced specificity.