Synthesis and antibacterial activities of some 1-[2-(substituted pyrrol-1-yl)ethyl]-2-methyl-5-nitroimidazole derivatives

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Atıf İçin Kopyala

Demirayak S., Karaburun A., Kiraz N.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.34, sa.3, ss.275-278, 1999 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 34 Sayı: 3
• Basım Tarihi: 1999
• Doi Numarası: 10.1016/s0223-5234(99)80062-2
• Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.275-278
• İstanbul Üniversitesi Adresli: Hayır

Özet

In this study, some 1-[2-(substituted pyrrol-1-yl)ethyl]-2-methyl-5-nitroimidazole derivatives were synthesized by reacting 2-(2-methyl-5-nitro-1H-imidazolyl)ethylamine dihydrochloride, which was prepared using metronidazole, with some 1,4-dicarbonyl compounds. The structure elucidation of the compounds was performed by IR, H-1-NMR and mass spectroscopic data and elemental analysis results. Antimicrobial activities of the compounds were examined and notable activity was obtained. (C) Elsevier, Paris.