Synthesis and antibacterial activities of some 1-[2-(substituted pyrrol-1-yl)ethyl]-2-methyl-5-nitroimidazole derivatives


Demirayak S., Karaburun A., Kiraz N.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.34, no.3, pp.275-278, 1999 (Journal Indexed in SCI) identifier identifier

Abstract

In this study, some 1-[2-(substituted pyrrol-1-yl)ethyl]-2-methyl-5-nitroimidazole derivatives were synthesized by reacting 2-(2-methyl-5-nitro-1H-imidazolyl)ethylamine dihydrochloride, which was prepared using metronidazole, with some 1,4-dicarbonyl compounds. The structure elucidation of the compounds was performed by IR, H-1-NMR and mass spectroscopic data and elemental analysis results. Antimicrobial activities of the compounds were examined and notable activity was obtained. (C) Elsevier, Paris.