Synthesis and antibacterial activities of some 1-[2-(substituted pyrrol-1-yl)ethyl]-2-methyl-5-nitroimidazole derivatives

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Demirayak S., Karaburun A., Kiraz N.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.34, no.3, pp.275-278, 1999 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 34 Issue: 3
• Publication Date: 1999
• Doi Number: 10.1016/s0223-5234(99)80062-2
• Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.275-278
• Istanbul University Affiliated: No

Abstract

In this study, some 1-[2-(substituted pyrrol-1-yl)ethyl]-2-methyl-5-nitroimidazole derivatives were synthesized by reacting 2-(2-methyl-5-nitro-1H-imidazolyl)ethylamine dihydrochloride, which was prepared using metronidazole, with some 1,4-dicarbonyl compounds. The structure elucidation of the compounds was performed by IR, H-1-NMR and mass spectroscopic data and elemental analysis results. Antimicrobial activities of the compounds were examined and notable activity was obtained. (C) Elsevier, Paris.