Flow Cytometry Analysis of Peripheral Blood B Cell Distribution of Patients with Multiple Sclerosis
TURKISH JOURNAL OF NEUROLOGY, vol.23, no.4, pp.219-224, 2017 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 23 Issue: 4
- Publication Date: 2017
- Doi Number: 10.4274/tnd.87523
- Journal Name: TURKISH JOURNAL OF NEUROLOGY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.219-224
- Keywords: Multiple sclerosis, B cell, peripheral blood, CLINICALLY ISOLATED SYNDROME, BRAIN
- Istanbul University Affiliated: Yes
Abstract
Objective: Multiple sclerosis (MS) is a central nervous system (CNS) disease characterized by autoimmune inflammation and neurodegeneration. Damage to the CNS is thought to be mediated predominantly by activated pro-inflammatory T cells and antibody secreting B cells. Strong evidence of B cell functions in MS pathogenesis has come from trials of B cell-depleting treatment. In this study, the peripheral blood frequencies of B cell subsets were measured using flow cytometry in patients to determine the disease-specific B cell differences that might be associated with the evolution to progressive forms of MS.