Flow Cytometry Analysis of Peripheral Blood B Cell Distribution of Patients with Multiple Sclerosis

Yilmaz V., Tura D. A., Ulusoy C., Yasargun D. O., Cinar S., Turkoglu R.

TURKISH JOURNAL OF NEUROLOGY, cilt.23, sa.4, ss.219-224, 2017 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tnd.87523
  • Dergi Adı: TURKISH JOURNAL OF NEUROLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.219-224
  • Anahtar Kelimeler: Multiple sclerosis, B cell, peripheral blood, CLINICALLY ISOLATED SYNDROME, BRAIN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Multiple sclerosis (MS) is a central nervous system (CNS) disease characterized by autoimmune inflammation and neurodegeneration. Damage to the CNS is thought to be mediated predominantly by activated pro-inflammatory T cells and antibody secreting B cells. Strong evidence of B cell functions in MS pathogenesis has come from trials of B cell-depleting treatment. In this study, the peripheral blood frequencies of B cell subsets were measured using flow cytometry in patients to determine the disease-specific B cell differences that might be associated with the evolution to progressive forms of MS.