Simvastatin improves spinal fusion in rats

Bostan B., GÜNEŞ T., AŞCI M., ŞEN C., Kelestemur M. H., Erdem M., ...More

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.45, no.4, pp.270-275, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.3944/aott.2011.2526
  • Journal Name: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.270-275
  • Keywords: BMP, pseudoarthrosis, simvastatin, spinal fusion, statin, DEMINERALIZED BONE-MATRIX, STATINS, FRACTURE, MODEL, INHIBITION, GROWTH
  • Istanbul University Affiliated: Yes

Abstract

Objective: Statins stimulate bone formation by inducing the expression of bone morphogenetic proteins (BMP-2). The aim of our study was to investigate the effects of orally administered simvastatin on spinal fusion in rats.