Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency


Oflaz H. , Sen F. , Elitok A. , CIMEN A. O. , Onur I. , Kasikcioglu E. , ...Daha Fazla

CLINICAL ENDOCRINOLOGY, cilt.66, ss.524-529, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 66 Konu: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1365-2265.2007.02767.x
  • Dergi Adı: CLINICAL ENDOCRINOLOGY
  • Sayfa Sayıları: ss.524-529

Özet

Objective Relationship between adult growth hormone deficiency (AGHD) and increased cardiovascular disease risk is very well known in hypopituitary patients treated with conventional hormone replacement therapy other than growth hormone (GH) administration. Endothelial dysfunction, an early and reversible event in pathogenesis of atherosclerosis, is associated with increased vascular smooth muscle tone, arterial stiffening and intima-media thickness (IMT). Coronary flow reserve (CFR) measurement by transthoracic Doppler echocardiography (TTDE) reflects coronary microvascular and endothelial functions, as a cheaper and an easy screening test. We have used TTDE to evaluate endothelial function and coronary microvascular function in AGHD.