Hereditary Thrombophilia, Anti-Beta2 Glycoprotein 1 IgM, and Anti-Annexin V Antibodies in Recurrent Pregnancy Loss


Karata S., Aydin Y., Ocer F., Buyru A. , Balci H.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol.67, no.3, pp.251-255, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1111/j.1600-0897.2011.01092.x
  • Title of Journal : AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
  • Page Numbers: pp.251-255

Abstract

PROBLEM:

We investigated the beta2-glycoprotein I and anti-annexin V antibodies as anti-phospholipid-cofactor antibodies; and factor V G1691A Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T mutations as hereditary thrombophilia in recurrent pregnancy losses (RPL).

METHOD OF STUDY:

Study group consisted of 84 women with recurrent pregnancy loss and control group consisted of 84 women having at least one live birth.

RESULTS:

Methylenetetrahydrofolate reductase C677T homozygous mutation was detected in 28.5% of the study group and in 14.2% of the controls, and the difference was highly significant (P < 0.001). Heterozygous mutation of this gene was found in 64.3% of the study population and in 38.1% of the controls, and difference in heterozygous mutation frequency was also significant (P < 0.001). Both homozygous and heterozygous mutations of PT G20210A and factor V G1691A were not different between the groups. There was no significant difference in anti-annexin V levels and anti-beta2-gp 1 levels of the groups.

CONCLUSION:

We concluded that both homozygous and heterozygous mutations of MTHFR C677T were related with RPL in Caucasian women.