Nucleophilic substitution reactions of 1,4-naphthoquinone and biologic properties of novel S-, S,S-, N-, and N,S-substituted 1,4-naphthoquinone derivatives

Ibis C., Tuyun A. F., Bahar H., Ayla S., Stasevych M. V., Musyanovych R. Y., ...More

MEDICINAL CHEMISTRY RESEARCH, vol.23, no.4, pp.2140-2149, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1007/s00044-013-0806-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2140-2149
  • Keywords: 1,4-Naphthoquinone, Amines, Thiols, Antibacterial activity, Antifungal activity, ANTIBACTERIAL, ANTIFUNGAL, ANTIPLATELET
  • Istanbul University Affiliated: Yes


A novel series of S-, S,S-, N- and N,S-substituted 1,4-naphthoquinone derivatives were synthesized and evaluated for their antibacterial and antifungal activity. Among the synthesized compounds especially 10a and 11b have been discovered as an antibacterial or antifungal agents, and 15f is the most effective compound against M. luteum as potent antifungal. The structures of the novel products were characterized by micro analysis, UV/Vis, H-1 NMR, C-13 NMR, and MS. The electrochemical properties of some of the novel 1,4-naphthoquinone derivatives were also investigated by cyclic voltammetry.