A solitary calvarial lytic lesion with typical histopathological findings of juvenile hyaline fibromatosis - Case report

Bas N., Guzey F., Emel E., Cefle K., Turgut H., Alatas I., ...More

JOURNAL OF NEUROSURGERY, vol.103, no.3, pp.285-288, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 3
  • Publication Date: 2005
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.285-288
  • Istanbul University Affiliated: Yes


Juvenile hyaline fibromatosis (JHF) is a rare systemic disease characterized by papulonodular skin lesions, gingivalhyperplasia, joint contractures, and osteolytic lesions on long bones and the skull. It has recently been reported that the disease is caused by mutations in the gene encoding capillary morphogenesis protein-2 (CMG-2). To date, fewer than 60 cases have been published in the literature. Partial disease expression is common, but no cases featuring a solitary calvarial lesion have been reported.