Association of polymorphisms in the sex hormone genes with the presence and severity of coronary artery disease

Coban N., Ozuynuk A. S., Erkan A. F., KAYA A., EKİCİ B., Guclu-Geyik F., ...More

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, vol.50, no.1, pp.22-33, 2022 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.5543/tkda.2022.17203
  • Journal Name: TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.22-33
  • Keywords: Coronary artery disease, genetics, estrogen receptor alpha, single nucleotide polymorphism, aromatase, ESTROGEN-RECEPTOR-ALPHA, SINGLE-NUCLEOTIDE POLYMORPHISM, BLOOD-PRESSURE, CYP19A1 GENE, POSTMENOPAUSAL WOMEN, INSULIN-RESISTANCE, RISK, HEART, CANCER, ATHEROSCLEROSIS
  • Istanbul University Affiliated: Yes

Abstract

Objective: Coronary artery disease (CAD) is an important public health problem worldwide. Therefore, it is important to identify the molecular mechanisms and the candidate gene polymorphisms involved in the development of CAD. In this study, we focused on 2 polymorphisms of the atherosclerosis-related genes, ESR1 and CYP19A1.