DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside


Goren A., Zhou B., Topcu G., Kokdil G., Kingston D.

NATURAL PRODUCT RESEARCH, vol.19, no.5, pp.457-460, 2005 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 19 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1080/14786410412331272095
  • Journal Name: NATURAL PRODUCT RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.457-460
  • Istanbul University Affiliated: No

Abstract

An iridoid glucoside reptoside ( 1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds ( 24S)-24-ethylcholesta-5,25-dien-3 beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.