DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside


Goren A., Zhou B., Topcu G., Kokdil G., Kingston D.

NATURAL PRODUCT RESEARCH, cilt.19, sa.5, ss.457-460, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/14786410412331272095
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.457-460
  • İstanbul Üniversitesi Adresli: Hayır

Özet

An iridoid glucoside reptoside ( 1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds ( 24S)-24-ethylcholesta-5,25-dien-3 beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.