Research Information System
2 nd INTERNATIONAL AQUATIC BIOTECHNOLOGY SYMPOSIUM, İstanbul, Turkey, 13 - 14 October 2021, pp.1, (Full Text)
Fluconazole inhibits ergosterol biosynthesis and this deficiency prevents fungal growth by
disrupting the structure of the fungal cell membrane.
3 42 genes that were fully sensitive and
33 genes that were semi-sensitive to 50 µg/ml fluconazole, 11 genes sensitive to 25 µg/ml
and 3 genes sensitive to 10 µg/ml fluconazole were identified. Three common genes were
identified that were sensitive to all three doses; rpl2301, rps2201 and pho7. These genes
were found to play a major role in protein synthesis. As a result of Table 1, it was
determined that the biological processes of the determined genes showed high diversity and
the lethal effect of fluconazole on cells was not dependent on a single mechanism, and as a
result of Table 2, the lethal activity of fluconazole was closely related to the binding
processes in the cell.