Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1-5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues

Ozkaya, Hande; Comunoglu, Nil; Sayitoglu, Müge; Keskin, Fatma; Firtina, Sinem; Khodzhaev, Khusan; Apaydin, Tugce; Gazioglu, Makbule; Tanriover, Necmettin; Oz, Ayşim; Kadioglu, Pınar

doi:10.1007/s11102-018-0876-4

Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1-5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues

Ozkaya H. M., Comunoglu N., Sayitoglu M., Keskin F. E., Firtina S., Khodzhaev K., ...More

PITUITARY, vol.21, pp.335-346, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 21
Publication Date: 2018
Doi Number: 10.1007/s11102-018-0876-4
Journal Name: PITUITARY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.335-346
Keywords: Somatostatin analogue, Receptor, Resistance, SECRETING PITUITARY-ADENOMAS, NEUROENDOCRINE TUMORS, SSTR2 EXPRESSION, OCTREOTIDE LAR, YOUNG-PATIENTS, SOMATOTROPINOMAS, PREVALENCE, RESISTANCE, COHORT, MACROADENOMAS
Istanbul University Affiliated: Yes

Abstract

Objective To determine aryl hydrocarbon interacting protein (AIP) gene variations and AIP and somatostatin receptor (SSTR) 1-5 immunostaining in patients with apparently sporadic acromegaly with poor versus good response to somatostatin analogues (SRLs).