CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies


van der Zanden L. F. M., van Rooij I. A. L. M., Quaedackers J. S. L. T., Nijman R. J. M., Steffens M., de Wall L. L. L., ...More

EUROPEAN UROLOGY OPEN SCIENCE, vol.28, pp.26-35, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28
  • Publication Date: 2021
  • Doi Number: 10.1016/j.euros.2021.04.001
  • Journal Name: EUROPEAN UROLOGY OPEN SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.26-35
  • Istanbul University Affiliated: No

Abstract

Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development. Objective: To identify genetic variants associated with kidney injury in patients with obstructive uropathy. Design, setting, and participants: We included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase.