Objective: This study was designed to evaluate the efficacy of mudpack therapy in 31 patients with chronic low back pain for more than 3 months. Material and Methods: In this study, that included 16 females and 15 males, the mean age was 49.23 (35-66) years. Mudpack therapy was applied at 45 degrees C for 30 minutes once a day for 12 days. All patients were evaluated using Visual Anlogue Scale (VAS), Beck Depression Inventory (BDI), Modified Schober Test (MST) and Short Form-36 (SF-36) scores. Results: All instruments were administered three times (before therapy, at the end of week 3 and at the end of the 3rd month). VAS, BDI, MST and SF-36 scores improved significantly (p< 0.001). Conclusion: We conclude that mudpack therapy gives satisfatory results in the early period for patients with chronic low back pain and improves quality of life and that it can be safely applied for these patients.