COVID-19-Endothelial Axis and Coronary Artery Bypass Graft Patency: a Target for Therapeutic Intervention?


Topal G. , Loesch A., Dashwood M. R.

BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY, vol.35, no.5, pp.757-763, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.21470/1678-9741-2020-0303
  • Title of Journal : BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
  • Page Numbers: pp.757-763
  • Keywords: COVID-19, SARS Virus, Coronary Artery Bypass Graft Surgery, Saphenous Vein, Endothelial Dysfunction, Vascular Inflammation, ENDOTHELIUM-DEPENDENT CONTRACTIONS, SCANNING-ELECTRON-MICROSCOPY, SAPHENOUS-VEIN, VASA VASORUM, VASCULAR-TONE, DYSFUNCTION, ACTIVATION, HYPOTHESIS, PREVENTION, COVID-19

Abstract

It has been reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces endothelial inflammation, therefore facilitating the progression of endothelial and vascular dysfunction in coronavirus disease 2019 (COVID-19) patients. Coronary artery bypass grafting (CABG) involves mainly the use of the saphenous vein (SV) and internal mammary artery as graft material in the stenosed coronary arteries. Unfortunately, graft patency of the SV is low due to endothelial dysfunction and inflammation. We propose that SARS-CoV-2 might cause vascular inflammation, endothelial dysfunction, and thrombosis in coronary artery bypass graft vessels by binding angiotensin-converting enzyme 2 receptor. Therefore, in this Special Article, we consider the potential influence of COVID-19 on the patency rates of coronary artery bypass graft vessels, mainly with reference to the SV. Moreover, we discuss the technique of SV graft harvesting and the therapeutic potential of focusing on endothelial dysfunction, vascular inflammation, and thrombosis for protecting coronary artery bypass grafts in COVID-19 infected CABG patients.