GSTT1 null genotype frequency in a Turkish population.


Oke B., Akbas F., Aydin M. , Berkkan H.

Archives of toxicology, cilt.72, ss.454-5, 1998 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 72
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1007/s002040050527
  • Dergi Adı: Archives of toxicology
  • Sayfa Sayıları: ss.454-5

Özet

In humans; glutathione-S-transferases (GSTs) are involved in the detoxification of xenobiotics. A deletion polymorphism in the glutathione S-transferase Theta 1 gene (GSTT1 null genotype) is associated with an increased risk of certain forms of cancer. The distribution of this polymorphism in 240 healthy individuals has been examined, using a polymerase chain reaction (PCR)-based method. The GSTT1 null genotype frequency was 20% in a Turkish Population.