Akademik Veri Yönetim Sistemi
WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES 2019, Paris, Fransa, 4 - 07 Nisan 2019, ss.370-371
Objective: To determine the effect of additional oral glutamine supplementation to Kegel exercise on pelvic floor strength and clinical parameters of urinary incontinence in females.
Methods: It is a randomized, double-blind study. Females with urinary incontinence were included. Digital test and a vaginal manometer were used for measuring the strength of the pelvic floor muscles. 24 h pad weight test was examined. Participants were randomized into 2 groups as oral glutamine 30 g/d and placebo. It was asked to use the supplementation and Kegel exercises to all participants for 3 months. Basic and 3rd month measurements were compared by paired sample T-test and Wilcoxon tests in each group. The progression between measurements at basic and 3rd months was compared between the groups by using Mann-Whitney U test. (Clinical Trials protocol ID: 2014/1203)
Results: There were 11 patients in the glutamine arm and 18 patients in the placebo arm. Mean age was 58.2±6.6 y. Mean BMI was 32.9±4.8 kg/m2. There was no age difference between the groups [glutamine 59±3.8, placebo 57.8±7.9 y, p>0.05]. In glutamine arm, vaginal muscle strength assessed by digital test was higher at the end of 3 months [2.9±0.7 vs. 4±0.9; 0-3 months respectively, p=0.014]; perineometer measurements were not statistically different [27.4±8.3 vs. 31.2±8.9; 0-3 months respectively, p>0.05]; 24 h pad weight was not different [p>0.05]. In placebo arm, there was statistically significant progress in vaginal muscle strength assessed by both digital test and perineometer, and 24 h pad weight (p values: 0.005, 0.011, 0.002, respectively). When we compare the progression scores between the groups; there was no statistically significant difference [p>0.05].
Conclusion: Our study suggests that glutamine supplementation does not provide additional benefit in the treatment of pelvic muscle sarcopenia in patients without protein-energy malnutrition.
Acknowledgement: This study is supported by Nestle Health Science.