Effect of epirubicin on H-3-thymidine labelling index in cultured L-strain cells
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, cilt.16, sa.1, ss.23-27, 1997 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 1
- Basım Tarihi: 1997
- Dergi Adı: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.23-27
- İstanbul Üniversitesi Adresli: Evet
Özet
The effect of epirubicin (EPI) on H-3-thymidine labelling index (H-3-TdR LI) of L-strain cells in culture was investigated. EPI concentrations of 0.001 mu g/ml, 0.01 mu g/ml and 0.1 mu g/ml were applied to the cells for 4, 8, 16 and 32 hours. Following the treatment with EPI, labelling process in H-3-TdR medium continued for 0, 2, 4, 8, 16, 20, 22, 25 and 30 hours. The results showed that EPI diminished labelling index of L-strain cells depends on time and applied concentrations. When compared to control this decrease was found statistically significant (p < 0.001) in each group.