EFFECT OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE POLYMORPHISMS ON THE PLASMA CONCENTRATIONS OF MYCOPHENOLIC ACID IN TURKISH RENAL TRANSPLANT PATIENTS

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Senturk Ciftci H., Tefik T., Savran Karadeniz M., Demir E., Nane I., Savran Oguz F., ...More

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.80, no.3, pp.104-110, 2017 (ESCI)

• Publication Type: Article / Article
• Volume: 80 Issue: 3
• Publication Date: 2017
• Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
• Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
• Page Numbers: pp.104-110
• Keywords: Renal transplantation, pharmacogenetics, immunosuppressive therapy, polymorphism, mycophenolic acid, UGT2B7 GENETIC POLYMORPHISMS, CLINICAL PHARMACOKINETICS, MOFETIL, RECIPIENTS, UGT1A9, IMPACT, IMMUNOSUPPRESSION, PHARMACODYNAMICS, PROMOTER, ENZYMES
• Istanbul University Affiliated: Yes

Abstract

Objective: The pharmacokinetics of mycophenolic acid (MPA) differ among individuals. MPA is primarily metabolized by uridine diphosphate-glucuronosyltransferase (UGT), and UGT2B7 is an important UGT for the glucuronidation of MPA. This study aimed to examine the pharmacokinetics of MPA in Turkish renal transplant patients with UGT2B7 His268Tyr (802C>T) polymorphisms.