EFFECT OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE POLYMORPHISMS ON THE PLASMA CONCENTRATIONS OF MYCOPHENOLIC ACID IN TURKISH RENAL TRANSPLANT PATIENTS

Senturk Ciftci H., Tefik T., Savran Karadeniz M., Demir E., Nane I., Savran Oguz F., ...Daha Fazla

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.80, sa.3, ss.104-110, 2017 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80 Sayı: 3
  • Basım Tarihi: 2017
  • Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.104-110
  • Anahtar Kelimeler: Renal transplantation, pharmacogenetics, immunosuppressive therapy, polymorphism, mycophenolic acid, UGT2B7 GENETIC POLYMORPHISMS, CLINICAL PHARMACOKINETICS, MOFETIL, RECIPIENTS, UGT1A9, IMPACT, IMMUNOSUPPRESSION, PHARMACODYNAMICS, PROMOTER, ENZYMES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The pharmacokinetics of mycophenolic acid (MPA) differ among individuals. MPA is primarily metabolized by uridine diphosphate-glucuronosyltransferase (UGT), and UGT2B7 is an important UGT for the glucuronidation of MPA. This study aimed to examine the pharmacokinetics of MPA in Turkish renal transplant patients with UGT2B7 His268Tyr (802C>T) polymorphisms.