Terpenoids, essential oil composition and fatty acids profile, and biological activities of Anatolian Salvia fruticosa Mill.
TURKISH JOURNAL OF CHEMISTRY, cilt.37, sa.4, ss.619-632, 2013 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 4
- Basım Tarihi: 2013
- Doi Numarası: 10.3906/kim-1303-25
- Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.619-632
- Anahtar Kelimeler: Lamiaceae, Salvia fruticosa, secondary metabolites, abietane diterpenoids, triterpenoids, essential oil, fatty oil, antioxidant, anticholinesterase, ROSMARINUS-OFFICINALIS, FAMILY LABIATAE, LAURUS-NOBILIS, CARNOSIC ACID, TRILOBA L., CONSTITUENTS, ANTIOXIDANT, ANTICHOLINESTERASE, DITERPENOIDS, LACTONE
- İstanbul Üniversitesi Adresli: Evet
Özet
The hexane and dichloromethane extracts, obtained by re-extraction of the methanol extract of Salvia fruticosa Mill., afforded 7 diterpenoids (carnosol, carnosic acid, carnosic acid 12-methyl ether, rosmadial, isorosmanol, ferruginol, and manool), 4 triterpenoids (alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and erythrodiol), a steroid (3-acetylsitosterol), and a flavone (salvigenin). The galls (apples) of the collected plant were separately extracted with hexane to afford fatty acids composed mainly of oleic acid (29%), palmitoleic acid (29%), and stearic acid (23.20%), which exhibited high anticholinesterase activity, particularly against BChE. The essential oil, obtained from the aerial parts of the plant, exhibited high AChE inhibitory activity, consisting of mainly 1,8-cineol (58.89%). The antioxidant activity according to 6 complementary tests and anticholinesterase potential of the methanol extracts and triterpenoids alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and sitosterol acetate were also investigated, and methanol extract exhibited the highest antioxidant and anticholinesterase activity, surpassing the other tested extracts and pure compounds.