Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk

Gungor Z., Anuurad E., Enkhmaa B., Zhang W., Kim K., Berglund L.

ATHEROSCLEROSIS, vol.223, no.1, pp.230-234, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 223 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1016/j.atherosclerosis.2012.04.021
  • Journal Name: ATHEROSCLEROSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.230-234
  • Istanbul University Affiliated: Yes

Abstract

Objective: Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties. We hypothesized that the presence of apo E-4 is associated with an increased inflammatory burden in subjects with CAD as compared to subjects without CAD.