Paraoxonase-1 55/192 genotypes in schizophrenic patients and their relatives in Turkish population
Psychiatric Genetics, vol.18, no.6, pp.289-294, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 6
- Publication Date: 2008
- Doi Number: 10.1097/ypg.0b013e3283060f94
- Journal Name: Psychiatric Genetics
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.289-294
- Keywords: oxidative stress, paraoxonase activity, paraoxonase polymorphism, relative, schizophrenia, LOW-DENSITY-LIPOPROTEIN, GAMMA-AMINOBUTYRIC ACID, THERAPEUTIC IMPLICATIONS, DIABETES-MELLITUS, OXIDATIVE STRESS, MOLECULAR-BASIS, FREE-RADICALS, RATING-SCALE, GENE PON1, SERUM
- Istanbul University Affiliated: Yes
Abstract
Background Oxidative stress and free radical-induced toxicity have been implicated in the pathophysiology of schizophrenia. In this study, we examined paraoxonase (PON1)-55/192 polymorphisms and PON1 activity in patients with schizophrenia, first-degree relatives of schizophrenic patients, and healthy controls.