Research Information System
in: Lipids in Pulmonary Drug Delivery, Md Faiyazuddin,Hasan Ali,Md Akbar,Babar Iqbal, Editor, Elsevier Science, Oxford/Amsterdam , Massachusetts, pp.337-352, 2025
Lipid-based formulations have lately gained attraction for pulmonary drug delivery because of their potential to enhance the solubility, stability, targeting, and bioavailability of drug compounds. Pulmonary drug delivery is an attractive and noninvasive administration choice that can be delivered by the pulmonary administration route for both local and systemic effects. Our aim in this chapter is to provide a complete review of the evaluation of lipid-based formulations for pulmonary delivery, including particle size, zeta potential, encapsulation efficiency, drug loading, in vitro studies, and in vivo studies. Toxicity studies in several cell culture models are also reviewed. In addition, the chapter discusses in vitro in vivo correlation, and in silico studies that have been performed to evaluate lipid-based formulations.