Effects of Femara and Tamoxifen on Proliferation of FM3A Cells in Culture
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.14, sa.5, ss.2819-2822, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 5
- Basım Tarihi: 2013
- Doi Numarası: 10.7314/apjcp.2013.14.5.2819
- Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2819-2822
- İstanbul Üniversitesi Adresli: Evet
Özet
In this study, antiproliferative effects of the selective estrogen receptor modulator Tamoxifen and the aromatase inhibitor letrozole (Femara) were evaluated and compared using the FM3A cell line, originating from a C3H mouse mammary carcinoma and positive in terms of estrogen receptor (ER) expression. Cell kinetic parameters including labelling index, mitotic index and labelling index were assessed after exposure of the. FM3A cell line to 0.001 mu g/ml of Tamoxifen and 0.25 mu g/ml of Femara for 4, 8, 16 and 32 h for all parameters. The results showed that cell growth was inhibited by both agents. There was a significant decrease in labelling index and mitotic index and significant increase in apoptotic index for all experimental groups. The differences between control and all experimental groups were statistically significant (p<0.001) for all applications.