The effects of serum levels, and alterations in the genes of binding protein and receptor of vitamin D on gastric cancer

Durak S., Gheybi A., Demirkol S., Arikan S., Zeybek S. U., Akyuz F., ...Daha Fazla

MOLECULAR BIOLOGY REPORTS, cilt.46, sa.6, ss.6413-6420, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s11033-019-05088-9
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6413-6420
  • Anahtar Kelimeler: Gastric cancer, VDR, VDBP, Vitamin D, Polymorphism, 25-HYDROXYVITAMIN D, D DEFICIENCY, POLYMORPHISMS, ASSOCIATION, RISK
  • İstanbul Üniversitesi Adresli: Evet

Özet

Due to many biological cell functions of vitamin D including regulation of cell survival, proliferation and differentiation, the metabolism of itself gains importance in the development of several types of cancer. This case-control study was designed to evaluate the risk of gastric cancer development in terms of VDR rs2228570 & rs731236, and VDBP rs7041 polymorphisms, and serum levels of vitamin D. The study consists of 77 gastric cancer patients and 84 healthy individuals. VDR and VDBP gene polymorphisms and vitamin D levels were determined by using PCR-RFLP and HPLC methods. The distribution of VDR or VDBP gene variants were not different in study groups. The serum level of 25-hydroxyvitamin D was significantly lower in gastric cancer patients versus controls (16 +/- 6 -> 11 +/- 6 ng/ml) in which male patients have higher levels than females. Although the whole study population lacks normal levels of 25-hydroxyvitamin D, it was found that the risk of the development of gastric cancer was approximately fourfold higher in cases with severe vitamin D (<10 ng/ml) deficiency. Our results indicate that VDR rs731236 & rs2228570 or VDBP rs7041 polymorphisms were not risk factors for the development of gastric cancer individually, however, lower serum levels of vitamin D may be a contributory risk for both predisposition and development of gastric cancer.