Levels of tumour necrosis factor-alpha and IL-1a in newly diagnosed and multidrug resistant tuberculosis

Cagatay T., Kiran B., Yurt S., Gulbaran Z., Kosar F., Cagatay P.

RESPIROLOGY, cilt.10, sa.3, ss.290-294, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1440-1843.2005.00711.x
  • Dergi Adı: RESPIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.290-294
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: The pro-inflammatory cytokines tumour necrosis factor (TNF)-alpha and IL-1 alpha play key roles in host defence against tuberculosis (TB) but there is little knowledge of their levels in multi-drug resistant TB (MDR-TB). The aim of the present study was to investigate the levels of TNF-alpha and IL-1 alpha and their relationship with the levels of T helper (CD4'), T suppressor (CD8') and total lymphocytes (CD45(+)) in newly diagnosed TB (N-TB) and MDR-TB.