Levels of tumour necrosis factor-alpha and IL-1a in newly diagnosed and multidrug resistant tuberculosis

Cagatay T., Kiran B., Yurt S., Gulbaran Z., Kosar F., Cagatay P.

RESPIROLOGY, vol.10, no.3, pp.290-294, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1440-1843.2005.00711.x
  • Journal Name: RESPIROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.290-294
  • Istanbul University Affiliated: Yes


Background: The pro-inflammatory cytokines tumour necrosis factor (TNF)-alpha and IL-1 alpha play key roles in host defence against tuberculosis (TB) but there is little knowledge of their levels in multi-drug resistant TB (MDR-TB). The aim of the present study was to investigate the levels of TNF-alpha and IL-1 alpha and their relationship with the levels of T helper (CD4'), T suppressor (CD8') and total lymphocytes (CD45(+)) in newly diagnosed TB (N-TB) and MDR-TB.