Effects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, vol.67, no.13, pp.979-986, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 67 Issue: 13
- Publication Date: 2004
- Doi Number: 10.1080/15287390490447278
- Journal Name: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.979-986
- Istanbul University Affiliated: No
Abstract
The aim of this study was to determine the effects of streptozotocin-induced diabetes on plasma reduced glutathione (GSH) and S-nitrosoglutathione (CSNO) levels. Further, the study investigated whether an antioxidant, pineal hormone melatonin, could protect against STZ-induced effects. STZ significantly decreased plasma GSH but increased the levels of plasma GSNO. Daily supplementation with melatonin restored plasma thiol to control values. Data suggest that STZ-induced hyperglycemia and compounds that act as scavengers of free radicals and peroxynitrite like melatonin may exert protection against STZ-incluced toxicity.