Effects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats

Gorgun, FM; Kokoglu, E; Gumustas, MK; Altug, T; Cansever, S; Kavunoglu, G

doi:10.1080/15287390490447278

Effects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats

Atıf İçin Kopyala

Gorgun F., Kokoglu E., Gumustas M., Altug T., Cansever S., Kavunoglu G.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, cilt.67, sa.13, ss.979-986, 2004 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 67 Sayı: 13
Basım Tarihi: 2004
Doi Numarası: 10.1080/15287390490447278
Dergi Adı: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.979-986
İstanbul Üniversitesi Adresli: Hayır

Özet

The aim of this study was to determine the effects of streptozotocin-induced diabetes on plasma reduced glutathione (GSH) and S-nitrosoglutathione (CSNO) levels. Further, the study investigated whether an antioxidant, pineal hormone melatonin, could protect against STZ-induced effects. STZ significantly decreased plasma GSH but increased the levels of plasma GSNO. Daily supplementation with melatonin restored plasma thiol to control values. Data suggest that STZ-induced hyperglycemia and compounds that act as scavengers of free radicals and peroxynitrite like melatonin may exert protection against STZ-incluced toxicity.