Graft survival and clinical outcomes of Descemet membrane endothelial keratoplasty: long-term results

Besek N. K., Yalcinkaya G., Kirgiz A., ÇAKMAK S., Genc S., Nacaroglu S. A., ...Daha Fazla

INTERNATIONAL OPHTHALMOLOGY, cilt.42, sa.1, ss.269-279, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s10792-021-02078-4
  • Dergi Adı: INTERNATIONAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.269-279
  • Anahtar Kelimeler: Ocular surface surgery, Corneal dystrophies, Corneal degenerations, Corneal transplantation, Diseases of the ocular surface, DETACHMENT
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Purpose The aim is to report long-term graft survival rates and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK). Methods In this study 150 eyes that underwent DMEK whether for Fuchs endothelial corneal dystrophy (FECD) or for bullous keratopathy (BK) surveilled for 7 years at 6 time points to evaluate graft survival rates and clinical outcomes of post-corneal transplantation. Results Overall, the estimated survival probability of 95% confidence interval at 7 years of post-DMEK was 0.58 (0.72-0.77), and the survival probabilities of eyes operated for FECD (0.53) were higher than eyes operated for BK (0.42) (log rank 26.87, [p = 0.197]). Post-transplant eyes with FECD achieved better visual acuity levels than eyes with BK (p = 0.006). Primary graft failure occurred in 11.3% eyes. Secondary graft failure rate was 9.3%, and allograft rejection rate was 4.7%. Conclusion Although DMEK is effective and safe in long term, visual results and graft survival rates are better in cases with FECD.