Bimodal Pattern of Coronary Microvascular Involvement in Diabetes Mellitus

Sezer, Murat; Kocaaga, Mehmet; Aslanger, Emre; Atici, Adem; Demirkiran, Ahmet; Bugra, Melike; Umman, Sabahattin; Umman, Berrin

doi:10.1161/jaha.116.003995

Bimodal Pattern of Coronary Microvascular Involvement in Diabetes Mellitus

Sezer M., Kocaaga M., Aslanger E., Atici A., Demirkiran A., Bugra Z., ...More

JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol.5, no.11, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 5 Issue: 11
Publication Date: 2016
Doi Number: 10.1161/jaha.116.003995
Journal Name: JOURNAL OF THE AMERICAN HEART ASSOCIATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Istanbul University Affiliated: Yes

Abstract

Background-The contribution of functionally disturbed coronary autoregulation and structurally impaired microvascular vasodilatory function to reduced coronary flow velocity reserve, reflecting impaired coronary microcirculation in diabetes mellitus (DM), has not been clearly elucidated. The objective of this study was to identify the mechanism of coronary microvascular impairment in DM in relation to duration of disease.