The diaphragm, as the central muscle of respiration, plays a vital role in breathing, trunk stability, and the regulation of intra-abdominal pressure. It is integral to numerous physiological processes and significantly impacts both respiratory and systemic health. This article explores the clinical spectrum of diaphragmatic dysfunctions and analyzes their multifaceted causes, which range from neurological disorders to mechanical restrictions. Diaphragmatic dysfunctions represent a commonly overlooked medical issue that can manifest in symptoms such as dyspnea, sleep disturbances, chronic fatigue, gastroesophageal reflux, and even heart failure. The etiology of such dysfunctions is diverse, including factors like chronic stress, myofascial trigger points, scar tissue, and mechanical trauma, all of which can irritate or impair the function of the phrenic nerve. Phrenic nerve impairment not only limits diaphragmatic movement but also disrupts the regulation of the autonomic nervous system and organ function. The combination of neural therapy and manual medicine has proven to be a promising therapeutic approach. Targeted injections at myofascial trigger points and segmental therapies can effectively release adhesions and significantly enhance diaphragmatic function. In addition, manual diagnostics enable precise identification of segmental dysfunctions and fascial restrictions. This integrative approach addresses not only localized biomechanical dysfunctions but also leverages the regulatory potential of the autonomic nervous system. The synergy between neural therapy and manual medicine offers new perspectives for treating these frequently misdiagnosed and undervalued medical conditions.