A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia

Ng O. H., Firtina S., Can I., Karakas Z., Agaoglu L., Dogru O., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.32, ss.127-135, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4274/tjh.2013.0296
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.127-135
  • Anahtar Kelimeler: WNT5A, Methylation, Downregulation, Gene expression, ALL, TUMOR-SUPPRESSOR, GROWTH-FACTOR, BETA-CATENIN, HUMAN WNT-5A, EXPRESSION, PROLIFERATION, METHYLATION, PATHWAY, MALIGNANCIES, CARCINOMA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether hypermethylation might be the cause of low WNT5A mRNA levels and whether we could restore this downregulation by reversing the event.