A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia

Ng, Özden; Firtina, Sinem; Can, Ismail; Karakas, ZEYNEP; Agaoglu, Leyla; Dogru, Omer; Celkan, Tiraje; Akcay, Arzu; Yildirmak, Ytldiz; Timur, Cetin; Ozbek, UĞUR; Sayitoglu, MÜGE

doi:10.4274/tjh.2013.0296

A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia

Ng O. H., Firtina S., Can I., Karakas Z., Agaoglu L., Dogru O., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.32, pp.127-135, 2015 (SCI-Expanded, Scopus, TRDizin)

Publication Type: Article / Article
Volume: 32
Publication Date: 2015
Doi Number: 10.4274/tjh.2013.0296
Journal Name: TURKISH JOURNAL OF HEMATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.127-135
Keywords: WNT5A, Methylation, Downregulation, Gene expression, ALL, TUMOR-SUPPRESSOR, GROWTH-FACTOR, BETA-CATENIN, HUMAN WNT-5A, EXPRESSION, PROLIFERATION, METHYLATION, PATHWAY, MALIGNANCIES, CARCINOMA
Istanbul University Affiliated: Yes

Abstract

Objective: WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether hypermethylation might be the cause of low WNT5A mRNA levels and whether we could restore this downregulation by reversing the event.