A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct

Uzun, Samet; Alpay, N.; Öztürk, Gürcan; Saka, Bülent; Yenerel, Mustafa; Erten, N.; Karan, Mehmet; Tascioglu, C.

doi:10.1111/j.1751-553x.2007.00949.x

A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct

Atıf İçin Kopyala

Uzun S., Alpay N., Öztürk G., Saka B., Yenerel M. N., Erten N., ...Daha Fazla

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, sa.3, ss.248-253, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Basım Tarihi: 2008
Doi Numarası: 10.1111/j.1751-553x.2007.00949.x
Dergi Adı: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.248-253
İstanbul Üniversitesi Adresli: Evet

Özet

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by intravascular hemolysis, hemoglobinuria, and thrombosis. Thrombotic attacks are life threatening and are responsible for nearly 50% of PNH-related deaths. Compared with thrombotic events, bleeding related to thrombocytopenia in PNH is quite rare. This report describes an atypical clinical presentation with problems in the diagnosis and management of a woman who presented with a splenic infarct followed by massive intra-abdominal bleeding due to splenic rupture. She also developed a renal infarct during hospitalization after diagnosis.