A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct


Uzun S., Alpay N., Öztürk G., Saka B., Yenerel M. N. , Erten N., ...More

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, vol.30, no.3, pp.248-253, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1751-553x.2007.00949.x
  • Title of Journal : INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
  • Page Numbers: pp.248-253

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by intravascular hemolysis, hemoglobinuria, and thrombosis. Thrombotic attacks are life threatening and are responsible for nearly 50% of PNH-related deaths. Compared with thrombotic events, bleeding related to thrombocytopenia in PNH is quite rare. This report describes an atypical clinical presentation with problems in the diagnosis and management of a woman who presented with a splenic infarct followed by massive intra-abdominal bleeding due to splenic rupture. She also developed a renal infarct during hospitalization after diagnosis.