A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct


Uzun S., Alpay N., Öztürk G., Saka B., Yenerel M., Erten N., ...Daha Fazla

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, cilt.30, ss.248-253, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1111/j.1751-553x.2007.00949.x
  • Dergi Adı: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
  • Sayfa Sayıları: ss.248-253

Özet

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by intravascular hemolysis, hemoglobinuria, and thrombosis. Thrombotic attacks are life threatening and are responsible for nearly 50% of PNH-related deaths. Compared with thrombotic events, bleeding related to thrombocytopenia in PNH is quite rare. This report describes an atypical clinical presentation with problems in the diagnosis and management of a woman who presented with a splenic infarct followed by massive intra-abdominal bleeding due to splenic rupture. She also developed a renal infarct during hospitalization after diagnosis.