Struvite stones, which have also been referred to as "infection stones," are commonly encountered and constitute a significant group. The presence of urinary tract infection with a urease-producing organism is necessary for these stones to form. If left untreated, struvite calculi pose a significant risk to kidney and also to the patient's life. For this reason, the mainstay of treatment is complete removal of stones. Medical management is also an essential part of the treatment, especially due to the increased risk of recurrence. The aim of this chapter is to review the medical management options for struvite stones.