Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens


Zhao G., Zaidi T. S. , Bozkurt-Guzel C. , Zaidi T. H. , Lederer J. A. , Priebe G. P. , ...Daha Fazla

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, cilt.57, sa.15, ss.6797-6804, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Konu: 15
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1167/iovs.16-20358
  • Dergi Adı: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
  • Sayfa Sayıları: ss.6797-6804

Özet

PURPOSE. Developing immunotherapies for fungal eye infections is a high priority. We analyzed fungal pathogens for expression of the surface polysaccharide, poly-N-acetyl glucosamine (PNAG), and used a mouse model of ocular keratitis caused by Aspergillus flavus, A. fumigatus, or Fusarium solani to determine if PNAG was an immunotherapy target and requirements for ancillary cellular and molecular immune effectors.