Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens

Zhao, Ge; Zaidi, Tanweer; Bozkurt-Guzel, ÇAĞLA; Zaidi, Tauqeer; Lederer, James; Priebe, Gregory; Pier, Gerald

doi:10.1167/iovs.16-20358

Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens

Zhao G., Zaidi T. S., Bozkurt-Guzel C., Zaidi T. H., Lederer J. A., Priebe G. P., ...More

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol.57, no.15, pp.6797-6804, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 57 Issue: 15
Publication Date: 2016
Doi Number: 10.1167/iovs.16-20358
Journal Name: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.6797-6804
Istanbul University Affiliated: Yes

Abstract

PURPOSE. Developing immunotherapies for fungal eye infections is a high priority. We analyzed fungal pathogens for expression of the surface polysaccharide, poly-N-acetyl glucosamine (PNAG), and used a mouse model of ocular keratitis caused by Aspergillus flavus, A. fumigatus, or Fusarium solani to determine if PNAG was an immunotherapy target and requirements for ancillary cellular and molecular immune effectors.