Impaired memory by hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic fields is ameliorated by thymoquinone

ÜSTÜNOVA S., KILIÇ A., Bulut H., Gurel-Gurevin E., ERİŞ A. H., MERAL İ.

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, cilt.104, ss.176-193, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 104
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/02772248.2022.2051509
  • Dergi Adı: TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Compendex, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.176-193
  • Anahtar Kelimeler: 900 MHz EMF, cognitive functions, hippocampus, oxidative stress, thymoquinone, NIGELLA-SATIVA, RADIOFREQUENCY RADIATION, COGNITIVE IMPAIRMENT, PHONE, BRAIN, PREVENTS, DAMAGE, INFLAMMATION, PARAMETERS, NEURONS
  • İstanbul Üniversitesi Adresli: Evet

Özet

The protective effects of thymoquinone on learning and memory abilities and on hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength of 6.0 +/- 0.5 V/m for 1 h on each of 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) of radiation-exposed rats resulted in better performance than that of radiation-exposed rats not receiving thymoquinone. Electromagnetic field-exposure led to increased hippocampal superoxide dismutase, glutathione peroxidase, and malondialdehyde levels and to lowered brain-derived neurotrophic factor level; thymoquinone treatment ameliorated all four parameters. Also, in the electromagnetic field-exposed group, N-methyl-D-aspartate receptor expression decreased, and gamma-aminobutyric-acid alpha receptor expression increased, which was reversed by thymoquinone treatment. In conclusion, treatment with the thymoquinone ameliorated the impact of the exposure to EMF and provided a hint on the mechanism involving oxidative stress.