Synthesis, structure elucidation and antimicrobial activity of some 3-hydroxy-2-naphthoic acid hydrazide derivatives

Dogan H., Rollas S., Erdeniz H.

FARMACO, vol.53, no.7, pp.462-467, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 7
  • Publication Date: 1998
  • Doi Number: 10.1016/s0014-827x(98)00049-4
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.462-467
  • Istanbul University Affiliated: No


In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2-naphthoic acid hydrazide were synthesized to screen for their antimicrobial activity. The structures of these substances were elucidated using elemental analysis and UV, H-1 NMR, and mass spectral methods. All of these compounds were tested in vitro for their antibacterial and antifungal activity. (C) 1998 Elsevier Science S.A. All rights reserved.