The role of mdr1 gene polymorphisms in type 2 Diabetes Mellitus

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Atıf İçin Kopyala

Karatoprak O., Karaali Z. E., Incekara K., Celik F., Zeybek U., Ergen H. A., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.38, sa.2, ss.186-192, 2013 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 38 Sayı: 2
• Basım Tarihi: 2013
• Doi Numarası: 10.5505/tjb.2013.41736
• Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.186-192
• İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The ABCB1/MDR1 is a 170-kDa transporter protein called P-glycoprotein (P-gp) which has been associated with the transport of cellular lipids and drugs. Recent studies focused on MDR1, and its effects on lipid transport, show that the constitutive expression of P-gp transporter in normal tissues plays an important role in drug disposition and response. In addition, it is known that some polymorphisms on the MDR1 gene alter the expression of the P-gp. This study aims to investigate the effects of the MDR1 C3435T and the C1236T gene polymorphisms on the dyslipidemia of diabetic patients.