The role of mdr1 gene polymorphisms in type 2 Diabetes Mellitus


Karatoprak O., Karaali Z. E. , Incekara K., Celik F., Zeybek U. , Ergen H. A. , ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.38, ss.186-192, 2013 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 38 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5505/tjb.2013.41736
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.186-192

Özet

Objective: The ABCB1/MDR1 is a 170-kDa transporter protein called P-glycoprotein (P-gp) which has been associated with the transport of cellular lipids and drugs. Recent studies focused on MDR1, and its effects on lipid transport, show that the constitutive expression of P-gp transporter in normal tissues plays an important role in drug disposition and response. In addition, it is known that some polymorphisms on the MDR1 gene alter the expression of the P-gp. This study aims to investigate the effects of the MDR1 C3435T and the C1236T gene polymorphisms on the dyslipidemia of diabetic patients.