Cyclosporine-associated hyperkalemia: Report of four allogeneic blood stem-cell transplant cases

Caliskan Y., Kalayoglu-Besisik S. , Sargin D., Ecder T.

Transplantation, cilt.75, ss.1069-1072, 2003 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier


Background. Nephrotoxicity is a well-known effect of cyclosporine (CsA) that causes a reduction in glomerular filtration rate through vasoconstriction of the afferent glomerular arterioles and may result in acute renal failure. Isolated CsA-induced hyperkalemia occurring through different mechanisms is also common. However, there are only a few "case reports" addressing this phenomenon in allogeneic bone marrow transplantation patients. In this report, we propose mechanisms and methods of managing CsA-associated hyperkalemia in allogeneic transplantation.