Aspirin Resistance in Patients Undergoing Hemodialysis and Effect of Hemodialysis on Aspirin Resistance

Aksu H. U., Oner E., Celik O., Isiksacan N., Aksu H., Uzun S., ...Daha Fazla

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.21, sa.1, ss.82-86, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/1076029613489597
  • Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.82-86
  • Anahtar Kelimeler: aspirin resistance, hemodialysis, Multiplate test, STAGE RENAL-DISEASE, CARDIOVASCULAR-DISEASE, MYOCARDIAL-INFARCTION, PLATELET ACTIVATION, RISK, CLOPIDOGREL, PREVALENCE, MECHANISM, FAILURE, HISTORY
  • İstanbul Üniversitesi Adresli: Evet

Özet

The aim of this study was to evaluate the prevalence of aspirin resistance (AR) in patients undergoing hemodialysis (HD) and to assess the effect of HD on the results of the Multiplate test. A total of 54 patients undergoing HD were included in this study. Blood samples were taken just before and after the HD session. To determine AR, we used Multiplate test. Platelet aggregation values of the study population were 363.01 +/- 225.69 aggregation unit (AU) x minutes before and 375.33 +/- 254.05 AU x minutes after the HD (P = .597). There was strong correlation between the values before and after HD (R = .755, P < .0001). The AR status was changed in 9 (16.6%) patients after HD. Agreement of AR status before and after HD was substantial ( coefficient = .667, P < .0001). The prevalence of AR in patients undergoing HD seems higher than in most of the studied populations, and this study has shown that the AR statuses of a significant number of patients undergoing HD change after an HD session.