The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats

Karaoglan A., Akdemir O., Barut S., Kokturk S., Uzun H., Tasyurekli M., ...Daha Fazla

SURGICAL NEUROLOGY, cilt.70, sa.4, ss.337-343, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.surneu.2007.07.031
  • Dergi Adı: SURGICAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.337-343
  • Anahtar Kelimeler: Basilar artery, Cerebral vasospasm, Endothelin-1, Lipid peroxidation, Resveratrol, Superoxide dismutase, ENDOTHELIN RECEPTOR ANTAGONIST, BIOLOGICAL DEFENSE-MECHANISM, CEREBRAL VASOSPASM, CEREBROVASCULAR CHARACTERIZATION, ANTIPLATELET ACTIVITY, CEREBROSPINAL-FLUID, TRANS-RESVERATROL, OXIDATIVE STRESS, PATHOGENESIS, CLAZOSENTAN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Cerebral vasospasin remains a major cause of morbidity and mortality in patients with SAH. Although many pharmacologic agents and chemicals have been used to prevent and treat CV, the pathogenesis of that condition has not been established. We investigated the efficacy of resveratrol, a stilbene polyphenol and tyrosine kinase inhibitor that occurs naturally in grapes and red wine, in a murine basilar artery vasospasm model.