The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats


Karaoglan A., Akdemir O., Barut S., Kokturk S. , Uzun H. , Tasyurekli M., ...More

SURGICAL NEUROLOGY, vol.70, no.4, pp.337-343, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1016/j.surneu.2007.07.031
  • Journal Name: SURGICAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.337-343
  • Keywords: Basilar artery, Cerebral vasospasm, Endothelin-1, Lipid peroxidation, Resveratrol, Superoxide dismutase, ENDOTHELIN RECEPTOR ANTAGONIST, BIOLOGICAL DEFENSE-MECHANISM, CEREBRAL VASOSPASM, CEREBROVASCULAR CHARACTERIZATION, ANTIPLATELET ACTIVITY, CEREBROSPINAL-FLUID, TRANS-RESVERATROL, OXIDATIVE STRESS, PATHOGENESIS, CLAZOSENTAN
  • Istanbul University Affiliated: Yes

Abstract

Background: Cerebral vasospasin remains a major cause of morbidity and mortality in patients with SAH. Although many pharmacologic agents and chemicals have been used to prevent and treat CV, the pathogenesis of that condition has not been established. We investigated the efficacy of resveratrol, a stilbene polyphenol and tyrosine kinase inhibitor that occurs naturally in grapes and red wine, in a murine basilar artery vasospasm model.