SURGICAL NEUROLOGY, vol.70, no.4, pp.337-343, 2008 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Basilar artery, Cerebral vasospasm, Endothelin-1, Lipid peroxidation, Resveratrol, Superoxide dismutase, ENDOTHELIN RECEPTOR ANTAGONIST, BIOLOGICAL DEFENSE-MECHANISM, CEREBRAL VASOSPASM, CEREBROVASCULAR CHARACTERIZATION, ANTIPLATELET ACTIVITY, CEREBROSPINAL-FLUID, TRANS-RESVERATROL, OXIDATIVE STRESS, PATHOGENESIS, CLAZOSENTAN
Istanbul University Affiliated:
Background: Cerebral vasospasin remains a major cause of morbidity and mortality in patients with SAH. Although many pharmacologic agents and chemicals have been used to prevent and treat CV, the pathogenesis of that condition has not been established. We investigated the efficacy of resveratrol, a stilbene polyphenol and tyrosine kinase inhibitor that occurs naturally in grapes and red wine, in a murine basilar artery vasospasm model.