Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders

Jarius S., Jacobi C., de Seze J., Zephir H., Paul F., Franciotta D., ...More

MULTIPLE SCLEROSIS JOURNAL, vol.17, no.9, pp.1067-1073, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 9
  • Publication Date: 2011
  • Doi Number: 10.1177/1352458511403958
  • Journal Name: MULTIPLE SCLEROSIS JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1067-1073
  • Istanbul University Affiliated: Yes

Abstract

Background: A new autoantibody (termed NMO-IgG, or AQP4-Ab) has recently been described in patients with neuromyelitis optica (NMO) and its formes frustes, longitudinally extensive transverse myelitis (LETM) and recurrent optic neuritis (rON). However, AQP4-Ab has been found also in patients with co-existing rheumatic diseases such as systemic lupus erythematosus (SLE) or Sjogren's syndrome (SS), conditions which are characterized by broad, polyspecific B cell activation.