Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders


Jarius S., Jacobi C., de Seze J., Zephir H., Paul F., Franciotta D., ...Daha Fazla

MULTIPLE SCLEROSIS JOURNAL, cilt.17, ss.1067-1073, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 9
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/1352458511403958
  • Dergi Adı: MULTIPLE SCLEROSIS JOURNAL
  • Sayfa Sayıları: ss.1067-1073

Özet

Background: A new autoantibody (termed NMO-IgG, or AQP4-Ab) has recently been described in patients with neuromyelitis optica (NMO) and its formes frustes, longitudinally extensive transverse myelitis (LETM) and recurrent optic neuritis (rON). However, AQP4-Ab has been found also in patients with co-existing rheumatic diseases such as systemic lupus erythematosus (SLE) or Sjogren's syndrome (SS), conditions which are characterized by broad, polyspecific B cell activation.