Electrochemical design of two new sensors based on graphene nanoparticles and polymer resin -modified carbon paste electrodes for the determination of Tenofovir and Entecavir

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Aydoğmuş Z., Asfoor A., Şenkal B. F.

33rd International Symposium on Pharmaceutical and Biomedical Analysis (PBA2023) , Ankara, Türkiye, 2 - 06 Temmuz 2023, cilt.1, sa.1, ss.150, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Cilt numarası: 1
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.150
  • İstanbul Üniversitesi Adresli: Evet

Özet

Entecavir and Tenofovir, nucleos(t)ide analogs (NUCs), the

combination is recommended first-line therapy in multidrug-resistant

hepatitis B patients due to good tolerance, lower side-effect

profile, and high genetic barrier. This study reports the fabrication

of a novel polymer resin and graphene-modified carbon paste electrodes

for the simultaneous determination of the anti-HBV drugs entecavir (ETV) and tenofovir (TEV) in bulk and dosage form by

differential pulse voltammetry (DPV). The electrodes were specified

through cyclic voltammetry, and scanning electron microscopy

(SEM), and the analytical parameters were optimized. Both

drugs displayed clear oxidation peaks on the polymer resin and

graphene-modified carbon paste electrodes in the Britton-Robinson

buffer. The proposed method was successfully applied to the

simultaneous determination of ETV and TEV in commercial tablet

dosage forms, exhibiting good accuracy and precision. Moreover,

the addition of many excipients in the simultaneous analyzes

of TEN and ENT confirmed the anti-interference properties of

the fabricated sensors, as they did not affect the electrochemical

behavior of the substances.